An In Silico Approach Study: The Predicted Toxicity Profile of Diazinon
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Keywords:
Diazinon, Organophosphorus Pesticides, Protox 3.0, In Silico Approach, TESTAbstract
-The increased use of pesticides in the agricultural sector to meet global food demand, driven by
population growth. The widespread application of organophosphorus pesticides in crop production poses a
significant environmental problem related to the accumulation of residues in soil and surface water. The
presence of these organophosphorus residues can alter soil nutrient diversity, which is influential on
microorganisms responsible for soil fertility. Moreover, this agricultural-originated problem can cause toxic
effects to the ecosystem and human health. For that reason, the toxicity profile of diazinon (DZ), an
organophosphorus pesticide, was assessed by using two different in silico approaches. The predicted
toxicity of DZ was evaluated by using ProTox 3.0 and TEST programs. The results indicated that the DZ
pesticide exhibited toxic signs associated with the calculated lethal dose 50 (LD50) values.
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References
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