Mitochondrial Dysfunction and Diabetes

Abstract

Diabetes is a condition characterized by high blood sugar levels in the body and can lead to various long-term complications. Mitochondria are organelles responsible for energy production in our cells. Recent research indicates that diabetes can both cause and result from mitochondrial dysfunction. Diabetes can trigger mitochondrial DNA damage, oxidative stress, and inflammation due to mitochondrial dysfunction. Dysfunction in mitochondria can increase the production of free radicals, leading to increased oxidative stress. Oxidative stress can cause cellular damage and inflammation, thereby supporting the development of diabetes. Additionally, it is believed that diabetes can also affect mitochondrial processes such as mitochondrial biogenesis, mitochondrial mobility, and mitophagy.