SEROTONİNİN MEME KANSERİNDEKİ ROLÜ
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Keywords:
Serotonin, 5-HT, 5-HT Reseptörleri, Kanser, Kanser OluşumuAbstract
Serotonin (5-hidroksitriptamin, 5-HT), esansiyel amino asit triptofandan üretilen biyojenik bir
monoamindir. Serotoninin merkezi sinir sisteminde bir nörotransmiter ve gastrointestinal sistemde bir
motilite aracısı olarak rolü iyi tanımlanmıştır ve çeşitli kanserlerde (gliomalar, karsinoidler ve karsinomlar)
tümör oluşumundaki işlevi araştırılmaktadır. Birçok çalışma, serotoninin kanser hücresi çoğalması, istilası,
yayılması ve tümör anjiyogenezi üzerinde potansiyel uyarıcı etkisini göstermiştir. Altta yatan mekanizma
karmaşık olmasına rağmen tümördeki serotonin düzeylerinin ve bunun spesifik reseptör alt tipleri ile
etkileşiminin hastalığın ilerlemesi ile ilişkili olduğu öne sürülmektedir. Çeşitli çalışmalardan elde edilen
sonuçlar, tümörlerdeki serotonin düzeylerinin kanserin ilerlemesinde önemli bir rol oynadığını
göstermektedir. Serotonin reseptörleri, seçici serotonin taşıyıcıları ve serotonin sentez yolu, tedavi
seçeneklerinin sınırlı olduğu birçok kanserin tedavisinde potansiyel kemoterapötik hedeflerdir. Birçok
çalışma, serotoninin kanser hücresi çoğalması, istilası, yayılması ve tümör anjiyogenezi üzerinde potansiyel
uyarıcı etkisini göstermiştir. Altta yatan mekanizma karmaşık olmasına rağmen tümördeki serotonin
düzeylerinin ve bunun spesifik reseptör alt tipleri ile etkileşiminin hastalığın ilerlemesi ile ilişkili olduğu
öne sürülmektedir. Bu derleme makalesi, serotoninin ve meme kanser patogenezindeki rolünü
açıklamaktadır.
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