A study on investigation of the inhibition effects of some effective compounds for CD36 and LDL in atherosclerosis by using chemical computation method
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Keywords:
Aronia, Anthocyanin, Atorvastatin, Atherosclerosis, CD36, LDL, Hydroxycinnamic AcidAbstract
Aronia melanocarpa belongs to the Rosaceae family and is a shrub-shaped plant. Aronia fruits,
which are an important food source with their dark colored fruits and are also used in traditional
medicine, are also very rich in anthocyanins, flavonols and phenolic acids. Rich in polyphenols such as
anthocyanins, procyanidins and flavonoids.
The effects of aronia on inhibiting the progression of atherosclerotic plaque are being investigated. LDL
(low-density lipoprotein), which is synthesized in the liver and transported through the blood and is an
important parameter in determining the risk of heart disease, is a harmful form of cholesterol that
contributes to the development of atherosclerosis, a condition that can lead to heart attack through plaque
formation in the arteries. In the early stage of atherosclerosis, CD36 is essential, serving as a pattern
recognition receptor for non-classical monocyte functions through monitoring patrol activity and
mediating free fatty acid transport to hematopoietic stem cells in response to infections. In this study, the
interaction of CD36 and LDL, which have important roles in atherosclerosis, with natural active
compounds determined and selected through literature research using the chemical calculation method,
will be investigated. The data obtained is important in terms of providing direction for experimental and
clinical studies in this field by preventing loss of time and material.
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