HAZELNUT ALLERGY IN THE ALBANIAN POPULATION IN JULY-DECEMBER 2023 (Case study)
Abstract views: 24 / PDF downloads: 19
Keywords:
Allergic Reaction, IgE , Hazelnut, MonthAbstract
Introduction: Hazelnut is a common cause of systemic food-induced allergic reactions and anaphylaxis in
Europe, especially in young children. The purpose of this study is to identify the frequency of cases of
allergy caused by hazelnuts in the Albanian population in the period July-December 2023.
Materials and methods: 353 people of different age groups from the entire Albanian Republic participated
in this study. A venous blood sample was taken from each person to perform the specific IgE test for food
allergens using the Polycheck reagent with 30 total allergens.
Results and discussions: from the results of the laboratory tests it following:
• In July, there were a total of 61 patients, of which 12 (20%) were IgE+ for the hazelnut allergen.
• In August, there were 61 patients, of which 22 (36%) were IgE+ for the hazelnut allergen.
• In September, there were a total of 50 patients, of which 7 (14%) were IgE+ for the hazelnut.
• In October, there were 57 patients, of which 5 (8.8%) were IgE+ for the hazelnut allergen.
• In November, out of 51 total tests, 9 or (17.6%) of them resulted IgE+ for the hazelnut allergen.
• In December, out of 73 total tests, 13 (17.8%) resulted IgE+.
Conclusions: Hazelnut allergy is more pronounced in the summer season in our country (27.8%). The
month with the highest prevalence of hazelnut allergy is August.
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References
McWilliam, V.; Koplin, J.; Lodge, C.; Tang, M.; Dharmage, S.; Allen, K. The Prevalence of Tree Nut Allergy: A Sys-tematic Review. Curr. Allergy Asthma Rep. 2015, 15, 54. [CrossRef] [PubMed]
Grabenhenrich, L.B.; Dölle, S.; Moneret-Vautrin, A.; Köhli, A.; Lange, L.; Spindler, T.; Ruëff, F.; Nemat, K.; Maris, I.; Roumpedaki, E.; et al. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. J. Allergy Clin. Immunol. 2016, 137, 1128–1137.e1. [CrossRef] [PubMed]
Caffarelli, C.; Mastrorilli, C.; Santoro, A.; Criscione, M.; Procaccianti, M. Component-Resolved Diagnosis of Hazel-nut Allergy inChildren. Nutrients 2021, 13, 640. [CrossRef] [PubMed]
Pfeifer, S.; Bublin, M.; Dubiela, P.; Hummel, K.; Wortmann, J.; Hofer, G.; Keller, W.; Radauer, C.; Hoffmann-Sommergruber, K. Cor a 14, the allergenic 2S albumin from hazelnut, is highly thermostable and resistant to gastroin-testinal digestion. Mol. Nutr. Food Res. 2015, 59, 2077–2086. [CrossRef
Hofmann, C.; Scheurer, S.; Rost, K.; Graulich, E.; Jamin, A.; Foetisch, K.; Saloga, J.; Vieths, S.; Steinbrink, K.; Adler, H.S. Cor a1-reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen-associated food allergy to hazelnut. J. Allergy Clin. Immunol. 2013, 131, 1384–1392.e6. [CrossRef] [PubMed
Datema, M.R.; Zuidmeer-Jongejan, L.; Asero, R.; Barreales, L.; Belohlavkova, S.; de Blay, F.; Bures, P.; Clausen, M.; Dubakiene, R.;Gislason, D.; et al. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. J. Allergy Clin. Immunol. 2015, 136, 382–391. [CrossRef]
Offermann, L.R.; Bublin, M.; Perdue, M.L.; Pfeifer, S.; Dubiela, P.; Borowski, T.; Chruszcz, M.; Hoffmann-Sommergruber, K.Structural and Functional Characterization of the Hazelnut Allergen Cor a 8. J. Agric. Food Chem. 2015, 63, 9150–9158. [CrossRef][PubMed]
Le, T.M.; van Hoffen, E.; Lebens, A.F.M.; Bruijnzeel-Koomen, C.A.F.M.; Knulst, A.C. Anaphylactic versus mild reac-tions to hazelnut and apple in a birch-endemic area: Different sensitization profiles? Int. Arch. Allergy Immunol. 2013, 160, 56–62.[CrossRef]
Geiselhart, S.; Hoffmann-Sommergruber, K.; Bublin, M. Tree nut allergens. Mol. Immunol. 2018, 100, 71–81. [CrossRef]
Faber, M.A.; De Graag, M.; Van Der Heijden, C.; Sabato, V.; Hagendorens, M.M.; Bridts, C.H.; De Clerck, L.S.; Ebo, D.G. Cor a 14:Missing link in the molecular diagnosis of hazelnut allergy? Int. Arch. Allergy Immunol. 2014, 164, 200–206. [CrossRef]
Kattan, J.D.; Sicherer, S.H.; Sampson, H.A. Clinical reactivity to hazelnut may be better identified by component tes-ting than traditional testing methods. J. Allergy Clin. Immunol. Pract. 2014, 2, 633–634.e1. [CrossRef]
Masthoff, L.J.N.; Mattsson, L.; Zuidmeer-Jongejan, L.; Lidholm, J.; Andersson, K.; Akkerdaas, J.H.; Versteeg, S.A.; Garino, C.;Meijer, Y.; Kentie, P.; et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J. Allergy Clin. Immunol. 2013, 132, 393–399. [CrossRef] [PubMed]
Masthoff, L.J.N.; Blom, W.M.; Rubingh, C.M.; Klemans, R.J.B.; Remington, B.C.; Bruijnzeel-Koomen, C.A.F.M.; van Hoffen, E.;Houben, G.F.; Meyer, Y.; Pasmans, S.G.M.A.; et al. Sensitization to Cor a 9 or Cor a 14 has a strong impact on the distribution of thresholds to hazelnuts. J. Allergy Clin. Immunol. Pract. 2018, 6, 2112–2114.e1. [CrossRef] [PubMed]
Giovannini, M.; Comberiati, P.; Piazza, M.; Chiesa, E.; Piacentini, G.L.; Boner, A.; Zanoni, G.; Peroni, D.G. Retros-pective definition of reaction risk in Italian children with peanut, hazelnut and walnut allergy through component-resolved diagnosis. Allergol.Immunopathol. 2019, 47, 73–78. [CrossRef] [PubMed
Mastrorilli, C.; Cardinale, F.; Giannetti, A.; Caffarelli, C. Pollen-Food Allergy Syndrome: A not so Rare Disease in Childhood. Medicina 2019, 55, 641. [CrossRef]
Valcour, A.; Lidholm, J.; Borres, M.P.; Hamilton, R.G. Sensitization profiles to hazelnut allergens across the United States. Ann. Allergy Asthma Immunol. 2019, 122, 111–116.e1. [CrossRef] [PubMed]
Blanc, F.; Bernard, H.; Ah-Leung, S.; Przybylski-Nicaise, L.; Skov, P.S.; Purohit, A.; de Blay, F.; Ballmer-Weber, B.; Fritsche, P.; Rivas, M.F.; et al. Further studies on the biological activity of hazelnut allergens. Clin. Transl. Allergy 2015, 5, 26. [CrossRef]
Masthoff, L.J.; van Hoffen, E.; de Reus, A.; Boonacker, C.W.; Bruijnzeel-Koomen, C.A.; Pasmans, S.G.; Knulst, A.C. Hazelnut allergy differs between children and adults in frequency of severity, aetiology and relevance of diagnostic parameters. Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. 2014, 44, 1539–1545. [CrossRef]
Stiefel, G.; Anagnostou, K.; Boyle, R.J.; Brathwaite, N.; Ewan, P.; Fox, A.T.; Huber, P.; Luyt, D.; Till, S.J.; Venter, C.; et al. BSACI guideline for the diagnosis and management of peanut and tree nut allergy. Clin. Exp. Allergy 2017, 47, 719–739. [CrossRef]
Claudio Ortolani, MD,a Barbara K. Ballmer-Weber, MD,b Kirsten Skamstrup Hansen, MD,c Marco Ispano, MD,a Brunello Wüthrich, MD,b Carsten Bindslev-Jensen, MD, PhD, Dsc,d Raffaella Ansaloni, MD,a Luciana Vannucci, MD,a Valerio Pravettoni, MD,e Joseph Scibilia, MD,a Lars K. Poulsen, PhD,c and Elide A. Pastorello, Mde. Hazelnut allergy: A double-blind, placebo-controlled food challenge multicenter study Allergy Clin Immunol 2000 Mar;105(3):577-81. doi: 10.1067/mai.2000.103052
Ho, M.H.K.; Heine, R.G.; Wong, W.; Hill, D.J. Diagnostic accuracy of skin prick testing in children with tree nut al-lergy. J. Allergy Clin. Immunol. 2006, 117, 1506–1508. [CrossRef]
Inoue, Y.; Sato, S.; Takahashi, K.; Yanagida, N.; Yamamoto, H.; Shimizu, N.; Ebisawa, M. Component-resolved di-agnostics can be useful for identifying hazelnut allergy in Japanese children. Allergol. Int. 2020, 69, 239–245. [CrossRef]
Nebbia, S.; Lamberti, C.; Cirrincione, S.; Acquadro, A.; Abbà, S.; Ciuffo, M.; Torello Marinoni, D.; Manfredi, M.; Marengo, E.;Calzedda, R.; et al. Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children. Pediatr. Al-lergy Immunol. 2021, 32,1743–1755. [CrossRef]
Calvani, M.; Cardinale, F.; Martelli, A.; Muraro, A.; Pucci, N.; Savino, F.; Zappalà, D.; Panetta, V.; Alamazza, A.; Alessandri, C.;et al. Risk factors for severe pediatric food anaphylaxis in Italy. Pediatr. Allergy Immunol. 2011, 22, 813–819. [CrossRef]
Grabenhenrich, L.; Trendelenburg, V.; Bellach, J.; Yürek, S.; Reich, A.; Fiandor, A.; Rivero, D.; Sigurdardottir, S.; Cla-usen, M.; Papadopoulos, N.G.; et al. Frequency of food allergy in school-aged children in eight European countries—The EuroPrevalliFAAM birth cohort. Allergy 2020, 75, 2294–2308. [CrossRef]
Tagliati, S.; Barni, S.; Giovannini, M.; Liccioli, G.; Sarti, L.; Alicandro, T.; Paladini, E.; Perferi, G.; Azzari, C.; No-vembre, E.; et al.Nut Allergy: Clinical and Allergological Features in Italian Children. Nutrients 2021, 13, 4076. [CrossRef] [PubMed]
Haroun-Díaz, E.; Azofra, J.; González-Mancebo, E.; de Las Heras, M.; Pastor-Vargas, C.; Esteban, V.; Villalba, M.; Díaz-Perales, A.;Cuesta-Herranz, J. Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecu-lar Pattern. Nutrients 2017, 9, 909. [CrossRef]
Wood, R.A. The Natural History of Food Allergy. In Food Allergy; John Wiley & Sons Ltd.: Chichester, UK, 2014; pp. 464–474. ISBN 9781118744185
Masthoff, L.J.; van Hoffen, E.; de Reus, A.; Boonacker, C.W.; Bruijnzeel-Koomen, C.A.; Pasmans, S.G.; Knulst, A.C. Hazelnut allergy differs between children and adults in frequency of severity, aetiology and relevance of diagnostic parameters. Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. 2014, 44, 1539–1545. [CrossRef]
Erhard, S.M.; Bellach, J.; Yürek, S.; Tschirner, S.; Trendelenburg, V.; Grabenhenrich, L.B.; Fernandez-Rivas, M.; van Ree, R.; Keil, T.;Beyer, K. Primary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort study. Allergol. Int. 2021, 70, 463–470. [CrossRef]
25. Johnson, J.; Malinovschi, A.; Alving, K.; Lidholm, J.; Borres, M.P.; Nordvall, L. Ten-year review reveals changing trends and severity of allergic reactions to nuts and other foods. Acta Paediatr. 2014, 103, 862–867. [CrossRef] [PubMed]
Worm, M.; Scherer, K.; Köhli-Wiesner, A.; Ruëff, F.; Mahler, V.; Lange, L.; Treudler, R.; Rietschel, E.; Szepfalusi, Z.; Lang, R.; et al. Food-induced anaphylaxis and cofactors—Data from the anaphylaxis registry. Allergol. Sel. 2017, 1, 21–27. [CrossRef]
Povesi Dascola, C.; Caffarelli, C. Exercise-induced anaphylaxis: A clinical view. Ital. J. Pediatr. 2012, 38, 43. [CrossRef]
Matias, J.; Gaspar, A.; Sokolova, A.; Borrego, L.M.; Piedade, S.; Pires, G.; Arede, C.; Sampaio, G.; Morais Almeida, M. Tree nuts anaphylaxis in preschool age children. Eur. Ann. Allergy Clin. Immunol. 2020, 52, 182–186. [CrossRef]