Detection the genetic polymorphism and gene expression for apoptotic genes in patients with leukemia in Mosul city
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Keywords:
Apoptosis, Gene of Apoptosis, BAX, BCL-2, PCR, Mutation, Leukemia, Gene Expression, Q-PCRAbstract
Apoptosis is a highly regular process of programmed cell death to remove unwanted and
damaged cells. This process occurs due to several stimulations, some of them external, such as DNA
damage exposed to UV and toxin and bacteria or virus infection, and also some external stimulation, like
the absence of growth hormone apoptosis. Any defect in the process of apoptosis has an association with
many diseases, like cancer and autoimmune disorders. The BCL-2 and BAX genes belong to the BCL-2
family. These genes regulate the process of program cell death by inhabiting the process of apoptosis or
directing the cell toward death. Leukemia is the most common type of blood cancer in children younger
than 15. The characteristics by rapid or slow proliferation of cancer cells depend on the type of
leukemia.The objectives of this study are the determination of the genetic variation and detection of the
new mutation of BAX and BCL-2 in patients suffering from leukemia in Mosul city.According to the
following study, the proportion of kids with leukemia who observed the wild genotype was (20), the
proportion of mutant genotypes was (30), and the proportion of heterogeneous groups was 50 compared
with the healthy control group. 70% for wild genotype, 20% for the heterogeneous, and 10% for the
mutant genotype.
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