Identification of a Common Mutation in the SOD Gene in a Sterile Patients in Iraq/Mosul
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Keywords:
Sod, Genotypes, Infertility, Polymorphism, IraqAbstract
Infertility emerged as increased phenomenon around the world, and this became increased in Iraq
due to environmental pollutants and lifestyle. This study aimed to assess the relationship between
polymorphism in superoxide dismutase gene with infertility among Iraqi population in Mosul governate. The
present study included 130 infertile men with 20 healthy subjects as a control, blood samples were collected
from all persons under the study and DNA were extracted and subjected to conventional polymerase chain
reaction followed by gel electrophoresis to show the polymorphisms in visualized bands. The results of the
present study showed that there is polymorphism in SOD in multiple genotypes includes Val/Val, Val/Ala,
and Ala/Ala, and the Val/Ala and Ala/Ala genotypes were at a highest percentage (36% for both) while
Val/Val genotype was at 28%. This study concluded that there is a positive relationship between infertility
and polymorphism in SOD gene.
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