Investigation of Electrochemical Behavior of 3-Hydroxytyramine Hydrochloride Modified Pencil Graphite Electrode: Usability in Determination of Paracetamol
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Keywords:
Paracetamol, 3-hydroxytyramine hydrochloride, pencil graphite electrode, cyclic voltammetry, square wave voltammetryAbstract
In this study, in order to determine Paracetamol (PAR), a widely used antipyretic and
analgesic drug active ingredient due to its cheapness and easy availability, 3-hydroxytyramine
hydrochloride (3-HT) molecule was modified to pencil graphite electrode (PGE) surface with cyclic
voltammetry (CV) technique in +0.3/+2.0 V potential range and 100 mV s-1 scan rate for 10 cycles. The
electrochemical and spectroelectrochemical behaviors of 3-HT on PGE surface were investigated by CV,
electrochemical impedance spectroscopy (EIS) and linear scanning voltammetry (LSV) techniques. After
modification and chemical bonding processes, surface characterizations were compared with bare PGE
and 3-HT modified PGE surfaces by using ferrocene in nonaqueous medium and ferricyanide solutions in
aqueous medium with CV technique. Characterization studies performed by CV technique were
supported by EIS technique. Studies conducted at pH 2.0 in BR buffer solution using square wave
voltammetry (SWV) technique showed that PAR could be directly determined on the 3-HT modified PGE
surface.
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References
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