Investigation of Electrochemical Behavior of 3-Hydroxytyramine Hydrochloride Modified Pencil Graphite Electrode: Usability in Determination of Paracetamol

Abstract

In this study, in order to determine Paracetamol (PAR), a widely used antipyretic and analgesic drug active ingredient due to its cheapness and easy availability, 3-hydroxytyramine hydrochloride (3-HT) molecule was modified to pencil graphite electrode (PGE) surface with cyclic voltammetry (CV) technique in +0.3/+2.0 V potential range and 100 mV s-1 scan rate for 10 cycles. The electrochemical and spectroelectrochemical behaviors of 3-HT on PGE surface were investigated by CV, electrochemical impedance spectroscopy (EIS) and linear scanning voltammetry (LSV) techniques. After modification and chemical bonding processes, surface characterizations were compared with bare PGE and 3-HT modified PGE surfaces by using ferrocene in nonaqueous medium and ferricyanide solutions in aqueous medium with CV technique. Characterization studies performed by CV technique were supported by EIS technique. Studies conducted at pH 2.0 in BR buffer solution using square wave voltammetry (SWV) technique showed that PAR could be directly determined on the 3-HT modified PGE surface.