Investigation of Electrochemical Behavior of 3-Hydroxytyramine Hydrochloride Modified Pencil Graphite Electrode: Usability in Determination of Paracetamol
Abstract views: 26
/ 
PDF downloads: 23
Keywords:
Paracetamol, 3-hydroxytyramine hydrochloride, pencil graphite electrode, cyclic voltammetry, square wave voltammetryAbstract
In this study, in order to determine Paracetamol (PAR), a widely used antipyretic and
analgesic drug active ingredient due to its cheapness and easy availability, 3-hydroxytyramine
hydrochloride (3-HT) molecule was modified to pencil graphite electrode (PGE) surface with cyclic
voltammetry (CV) technique in +0.3/+2.0 V potential range and 100 mV s-1 scan rate for 10 cycles. The
electrochemical and spectroelectrochemical behaviors of 3-HT on PGE surface were investigated by CV,
electrochemical impedance spectroscopy (EIS) and linear scanning voltammetry (LSV) techniques. After
modification and chemical bonding processes, surface characterizations were compared with bare PGE
and 3-HT modified PGE surfaces by using ferrocene in nonaqueous medium and ferricyanide solutions in
aqueous medium with CV technique. Characterization studies performed by CV technique were
supported by EIS technique. Studies conducted at pH 2.0 in BR buffer solution using square wave
voltammetry (SWV) technique showed that PAR could be directly determined on the 3-HT modified PGE
surface.
Downloads
References
Goyal, R. N., & Singh, S. P. (2006). Voltammetric determination of paracetamol at C60-modified glassy carbon electrode. Electrochimica Acta, 51, 3008-3012.
Rajamani, A. R., & Peter, S. C. (2018). Novel nanostructured Pt/CeO2@Cu2O carbon – based electrode to magnify the electrochemical detection of the neurotransmitter dopamine and analgesic paracetamol. ACS Applied Nano Materials, 1, 5148.
Dalkiran, B., & Brett, C. M. A. (2021). A novel nanostructured poly(thionine)-deep eutectic solvent/CuO nanoparticle film-modified disposable pencil graphite electrode for determination of acetaminophen in the presence of ascorbic acid. Analytical and Bioanalytical Chemistry, 413, 1149-1157.
Korkmaz, Ş., Mülazımoğlu, İ. E., & Mülazımoğlu, A. Demir, (2024). Histamin modifiye çok duvarlı karbon nanotüp/katran/kalem grafit elektrot ile parasetamol tayini. Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, 6 (3). (INPRESS)
