Celiac Disease: Symptoms, Risk Factors, Causes, and Treatment
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DOI:
https://doi.org/10.5281/zenodo.14897875Keywords:
Celiac Disease, Serologic Tests, Symptoms, Treatments, Diagnosis, Autoimmune DisordersAbstract
Celiac disease, also known as celiac sprue, is a chronic inflammatory disorder of the small
intestine triggered by the ingestion of gluten in genetically predisposed individuals. This study
systematically reviews data on celiac disease and its treatment. The objectives include an overview of the
clinical manifestations, diagnostic methods, associated pathologies, and pharmacological and non
pharmacological treatment approaches. The methodology involved a literature review focusing on
epidemiology, pathogenesis, clinical presentation, diagnostic tests, and therapeutic management. The
results indicate that celiac disease is multifactorial, involving genetic and environmental factors. Genetic
testing and serological assays are among the most effective diagnostic tools. The disease is commonly
associated with thyroid disorders, liver diseases, osteoporosis, and neurological complications. A strict
gluten-free diet is the definitive treatment, although pharmacological interventions are necessary in
refractory cases.
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