Novel Vinyl Substituted N-Heterocyclic Carbene Silver(I) Complex: Synthesis and Structural Characterization
Abstract views: 11
/ 
PDF downloads: 14
Keywords:
Silver, Benzimidazolium, Ag-NHC, Synthesis, CharacterizationAbstract
Transition metal complexes of N-heterocyclic carbenes (NHCs) containing benzimidazole have
been at the center of intensive research in organometallic chemistry and homogeneous catalysis over the
years [1]. The electronic and steric properties of NHC complexes can be easily modified. This makes
carbene complexes indispensable in homogeneous catalysis. These complexes also have greater stability
against air, moisture and heat compared to their phosphine analogues [2]. In addition to catalysis, M-NHC
complexes are also widely used in the medical field. In addition to their antimicrobial effects, these
compounds have also been shown to be active against cancer. Research on the antimicrobial and anticancer
properties of silver has continued to increase in recent years and there are now many different silver
complexes that exhibit a wide spectrum of antimicrobial and anticancer activity [3]. The current research
work aims to provide alternatives to some products. In this study, a new 1-(4-vinylbenzyl)-3-(alkyl)-5,6
dimethylbenzimidazol-2-ylidene]silver(I) complexes were synthesized. The structures of all compounds
were characterized by 1H NMR, 13C NMR and IR spectroscopy techniques.properties.
Downloads
References
Hecel A, Kolkowska P, Krzywoszynska K, Szebesczyk A, Rowinska-Zyrek M, Kozlowski H. Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy. Curr Med Chem. 2019;26(4):624-7.
Cuin A, Massabni AC, Pereira GA, Leite CQ, Pavan FR, Sesti-Costa R, et al. 6-Mercaptopurine complexes with silver and gold ions: anti-tuberculosis and anti-cancer activities. Biomed Pharmacother. 2011;65(5):334-8.
Altay A, Caglar S, Caglar B, Sahin ZS. Novel silver (I) complexes bearing mefenamic acid and pyridine derivatives: Synthesis, chemical characterization and in vitro anticancer evaluation. Inorg Chim Acta. 2019;493:61-71.
Onar G, Karatas MO, Balcioglu S, Tok TT, Gurses C, Kilic-Cikla I, et al. Benzotriazole functionalized N-heterocyclic carbene–silver (I) complexes: Synthesis, cytotoxicity, antimicrobial, DNA binding, and molecular docking studies. Polyhedron. 2018;153:31-40.
Zheng MH, Bigdeli F, Gao LX, Wu DZ, Yan XW, Hu ML, et al. Synthesis, Characterization and DNA Binding Investigations of a New Binuclear Ag(I) Complex and Evaluation of Its Anticancer Property. Int J Nanomedicine. 2020;15:953-64.
B Naderizadeh and M. Bayat, Mendeleev Commun., 2021, 31, 179-181.
Gürbüz N, Özcan EÖ, Özdemir İ, Çetinkaya B, Şahin O, Büyükgüngör O, Preparation of a series of Ru( II) complexes with N-heterocyclic carbene ligands for the catalytic transfer hydrogenation of aromatic ketones, Dalton Trans., 2012, 41, 2330.
Naderizadeh B, Bayat M. Nature of metal–NHC bonds in some potential anticancer [(NHC (R)) 2→M]+(M= CuI, AgI, AuI, R= n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl)complexes. Mendeleev Commun. 2021;31(2):179-81.
Mohamed HA, Lake BR, Laing T, Phillips RM, Willans CE. Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine,theophylline and theobromine. Dalton Trans. 2015;44(16):7563-9.
