Formation of diazocyclic compounds from o-amino-biphenyl aromatics with nitric oxide: Investigation of the response of a fluorescent sensor containing coumarin and indoline salt to NO using DFT
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Keywords:
Fluorescent Probe, Coumarin, Indoline Salt, Nitric Oxide, NO, Diazo Cycle Formation, DFTAbstract
Reactive Oxygen Species (ROS), produced in biological reactions in living organisms, are
entities that can have significant chemical effects in cellular environments. While normal levels of ROS
production are positive, excessive production is negative. ROS are gasotransmitters and play important
roles in physiopathological processes. Furthermore, ROS are categorized as radicals (RO2.,-OH, NO.,
and O2.-) and non-radicals (HOCl, ONOO-, 1O2, H2O2, and O3). ROS are associated with oxidative stress
and are linked to various diseases triggered by it, such as cardiovascular disease, diabetes, and cancer.
Nitric oxide (NO.) is a gaseous molecule with a very short half-life. NO. plays a role in the regulation of
nerve function, making its identification crucial. Because NO. is a communication molecule in living
organisms, the development of simple and selective fluorescent sensors for its monitoring is invaluable.
Techniques for the determination of ROS include chromatography, Electron Spin Resonance, Nuclear
Magnetic Resonance, Mass Spectrometric Analysis, Chemiluminescence, and Fluorescence. While these
techniques are useful, the fluorescence method is superior. It is portable, requires no expertise, and is
inexpensive. Consequently, the results of applying Density Functional Theory (DFT) to the sensor
designed for NO. detection are analyzed here.
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