A study on the interaction and inhibition effect of some natural compound ligands with the 5p21 cancer receptor


Abstract views: 18 / PDF downloads: 23

Authors

  • Faik Gökalp Kırıkkale University

Keywords:

5p21, Carvacrol, Capsaicin, Curcumin and Docetaxel

Abstract

Some spices that we consume with foods in daily life add taste and aroma to meals eaten.
These spices are also very important for health. In this study, the interaction of the compounds
(Carvacrol,Capsaicin,Curcumin), the main active ingredients in some spices, consumed very frequently in
some societies, with 5p21, an important cancer receptor, has been determined by the chemical calculation
method, and the interaction points and possible bonds that could be formed at the molecular level has
been investigated to elucidate the mechanism.

Downloads

Download data is not yet available.

Author Biography

Faik Gökalp, Kırıkkale University

Faculty of Education, Science Education, Kırıkkale, Turkey

References

Pai, E.F., Wittinghofer, A., Kabsch, W. (1990) Refıned Crystal Structure Of The Trıphosphate Conformatıon Of H-Ras P21 At 1.35 Angstroms Resolutıon: Implıcatıons For The Mechanısm Of Gtp Hydrolysıs, PDB DOI: https://doi.org/10.2210/pdb5p21/pdb.

Balakrishnan, U., Kaliyaperumal, S., Egbuna, C., Chikwendu, C. J., Destiny, E. C., & Ibezim, E. N. (2022). Molecular Docking of Phytocompounds of Lamiaceae Family Targeting the Oncogene Protein [PDB ID: 5p21]. IPS Journal of Molecular Docking Simulations, 1(1), 11-17.

Ramesh, V., Subbarayan, K., Viswanathan, S., & Subramanian, K. (2024). Role of Nutraceuticals in the Management of Lifestyle Diseases. In Role of Herbal Medicines: Management of Lifestyle Diseases (pp. 461-478). Singapore: Springer Nature Singapore.

Mondal, A., Banerjee, S., Terang, W., Bishayee, A., Zhang, J., Ren, L., ... & Bishayee, A. (2024). Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression. Phytotherapy Research.

Bikadi, Z., & Hazai, E. (2009). Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock. Journal of cheminformatics, 1, 1-16.

Huey, R., Morris, G. M., Olson, A. J., & Goodsell, D. S. (2007). A semiempirical free energy force field with charge‐based desolvation. Journal of computational chemistry, 28(6), 1145-1152.

Bikadi, Z., Demko, L., & Hazai, E. (2007). Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot. Archives of Biochemistry and Biophysics, 461(2), 225-234.

McDonald, I. K., & Thornton, J. M. (1994). Satisfying hydrogen bonding potential in proteins. Journal of molecular biology, 238(5), 777-793.

Şenel, B., Başaran, E., Akyıl, E., Güven, U. M., & Büyükköroğlu, G. (2024). Co-Delivery of siRNA and Docetaxel to Cancer Cells by NLC for Therapy. ACS Omega.

Karakaya, M. F., Gökalp, F., Sener, E., & Korkmaz, O. T. (2023). Investigation of the Pharmacokinetic Properties and Theoretical Chemical Activities of 7, 8-Dihydroxyflavone and 4'-Dimethylamino-7, 8-Dihydroxyflavone. Current Pharmaceutical Analysis, 19(4), 317-323.

Gökalp, F. (2024). An investigation into the usage of black cumin derivatives against cancer and COVID-19 as the nature medicine. Journal of Biomolecular Structure and Dynamics, 1-8.

Gökalp, F. (2022). The curative effect of some natural active compounds for liver cancer. Medical Oncology, 40(1), 57.

Gökalp, F. (2022). An Investigation into the Usage of Monosaccharides with GLUT1 and GLUT3 as Prognostic Indicators for Cancer. Nutrition and Cancer, 74(2), 515-519.

Gökalp, F. (2020). The inhibition effect of natural food supplement active ingredients on TP63 carcinoma cell. Medical Oncology, 37(12), 120.

Gökalp, F. (2023). A study on natural control against nematodes and whiteflies with marigold, known as an Antagonist plant. Journal of Chemical Ecology, 49(5), 230-234.

Downloads

Published

2024-05-27

How to Cite

Gökalp, F. (2024). A study on the interaction and inhibition effect of some natural compound ligands with the 5p21 cancer receptor . International Journal of Advanced Natural Sciences and Engineering Researches, 8(4), 58–63. Retrieved from https://as-proceeding.com/index.php/ijanser/article/view/1820

Issue

Section

Articles