A Novel Framework for Accurate Multiclass Blood Cell Classification Using Deep Learning


Keywords:
CNN, Blood Cells, Plasma, RBC, Deep Learning, Imbalanced DatasetAbstract
This work introduces a new approach for classification of blood cells that handles issues
imbalance dataset between different categories and the presence of several classes. The main part of the
proposed approach is ResNet-18, a deep neural network designed for both strong and efficient feature
extraction and classification. We implemented class balancing techniques to eliminate the problem of
imbalanced classes in the training data. The model was able to classify Plasma Cell, Basophil, Eosinophils,
Erythroblast, Lymphocyte, Monocyte, nRBC and Platelet among the blood cell types. The study showed
that the model achieved an accuracy of 99.12%, precision of 99.12%, recall of 99.13% and F1-score of
99.12%. A deep learning framework makes blood cell analysis dependable and easily scalable, helping
solve major issues with classifying medical images.
Downloads
References
A. Girdhar, H. Kapur, and V. Kumar, "Classification of white blood cell using convolution neural network," Biomedical Signal Processing and Control, vol. 71, p. 103156, 2022.
K. Balasubramanian, N. Ananthamoorthy, and K. Ramya, "An approach to classify white blood cells using convolutional neural network optimized by particle swarm optimization algorithm," Neural Computing and Applications, vol. 34, no. 18, pp. 16089-16101, 2022.
R. B. Hegde, K. Prasad, H. Hebbar, and B. M. K. Singh, "Comparison of traditional image processing and deep learning approaches for classification of white blood cells in peripheral blood smear images," Biocybernetics and Biomedical Engineering, vol. 39, no. 2, pp. 382-392, 2019.
K. G. Dhal, R. Rai, A. Das, S. Ray, D. Ghosal, and R. Kanjilal, "Chaotic fitness-dependent quasi-reflected Aquila optimizer for superpixel based white blood cell segmentation," Neural Computing and Applications, vol. 35, no. 21, pp. 15315-15332, 2023.
R. I. Agustin, A. Arif, and U. Sukorini, "Classification of immature white blood cells in acute lymphoblastic leukemia L1 using neural networks particle swarm optimization," Neural Computing and Applications, vol. 33, no. 17, pp. 10869-10880, 2021.
W. Stock and R. Hoffman, "White blood cells 1: non-malignant disorders," The Lancet, vol. 355, no. 9212, pp. 1351-1357, 2000.
X. Yao, K. Sun, X. Bu, C. Zhao, and Y. Jin, "Classification of white blood cells using weighted optimized deformable convolutional neural networks," Artificial Cells, Nanomedicine, and Biotechnology, vol. 49, no. 1, pp. 147-155, 2021.
S. Khan, M. Sajjad, T. Hussain, A. Ullah, and A. S. Imran, "A review on traditional machine learning and deep learning models for WBCs classification in blood smear images," Ieee Access, vol. 9, pp. 10657-10673, 2020.
A. Patil, M. Patil, and G. Birajdar, "White blood cells image classification using deep learning with canonical correlation analysis," Irbm, vol. 42, no. 5, pp. 378-389, 2021.
S. Sharma et al., "[Retracted] Deep Learning Model for the Automatic Classification of White Blood Cells," Computational Intelligence and Neuroscience, vol. 2022, no. 1, p. 7384131, 2022.
A. Heni, I. Jdey, and H. Ltifi, "Blood Cells Classification Using Deep Learning with customized data augmentation and EK-means segmentation," J. Theor. Appl. Inf. Technol, vol. 101, no. 3, 2023.
M. A. Tahiri, A. Bencherqui, H. Karmouni, H. Amakdouf, M. Sayyouri, and H. Qjidaa, "White blood cell automatic classification using deep learning and optimized quaternion hybrid moments," Biomedical Signal Processing and Control, vol. 86, p. 105128, 2023.
N. Dong, Q. Feng, J. Chang, and X. Mai, "White blood cell classification based on a novel ensemble convolutional neural network framework," The Journal of Supercomputing, vol. 80, no. 1, pp. 249-270, 2024.
J. Ferdousi, S. I. Lincoln, M. K. Alom, and M. Foysal, "A deep learning approach for white blood cells image generation and classification using SRGAN and VGG19," Telematics and Informatics Reports, vol. 16, p. 100163, 2024.
H. Song and Z. Wang, "Automatic Classification of White Blood Cells Using a Semi-Supervised Convolutional Neural Network," IEEE Access, 2024
S. K. Pandey and A. K. Bhandari, "A systematic review of modern approaches in healthcare systems for lung cancer detection and classification," Archives of Computational Methods in Engineering, vol. 30, no. 7, pp. 4359-4378, 2023.
B. Leng, C. Wang, M. Leng, M. Ge, and W. Dong, "Deep learning detection network for peripheral blood leukocytes based on improved detection transformer," Biomedical Signal Processing and Control, vol. 82, p. 104518, 2023/04/01/ 2023, doi: https://doi.org/10.1016/j.bspc.2022.104518.
Z. Han et al., "One-stage and lightweight CNN detection approach with attention: Application to WBC detection of microscopic images," Computers in Biology and Medicine, vol. 154, p. 106606, 2023/03/01/ 2023, doi: https://doi.org/10.1016/j.compbiomed.2023.106606.
UncleSamulu. Blood Cells Image Dataset. [Online]. Available: https://www.kaggle.com/datasets/unclesamulus/blood-cells-image-dataset
M. Nickparvar. White blood cells dataset. [Online]. Available: https://www.kaggle.com/datasets/masoudnickparvar/white-blood-cells-dataset